Whole transcriptome sequencing (RNA-seq)
RNA sequencing is applied for in-depth analysis of whole transcriptomes, encompasses coding and non-coding RNAs (long ncRNA, small RNA, and circle RNA,etc.) for diverse research needs.
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Novogene's RNA-seq service offers:
- Illuminate the complexities of transcriptional and regulatory network while providing key insights into interaction functionalities
- Precisely quantify gene and transcript levels
- Exploring miRNA sponge and target regulatory elements
- Investigating regulatory networks among lncRNA/circRNA-miRNA-gene pairs
- Our whole transcriptome service is tailored to suit various research objectives. Powered by Illumina-based technology, it offers versatility across multiple biological inquiries, from detecting novel transcripts to deciphering alternative splicing patterns
<em>circPARD3</em> drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway
This case study integrates whole transcriptome sequencing with technical assistance from Novogene. Leveraging the advancement of circRNA sequencing, small RNA sequencing, and mRNA sequencing, the authors not only reveal the oncogenic role of circPARD3 in laryngeal squamous cell carcinoma (LSCC) but also indicate that circPARD3 can serve as a new biomarker and target for autophagy detection and modulation, which might be used for controlling autophagy levels in different developmental stages of LSCC.
