TCR-Like Antibody Development Solutions
End‑to‑end TCR‑like antibody services targeting peptide–MHC complexes—covering immunogen design, pMHC screening, affinity maturation, developability optimization, and functional validation—with output as IgG, bispecifics, or CAR constructs to access intracellular‑derived antigens.
TCR-Like Antibody Development Solutions
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Creative Biolabs provides TCR‑like antibody discovery and engineering services to target peptide–MHC complexes with antibody formats, enabling selective recognition of intracellular‑derived antigens using soluble, manufacturable molecules.
Services include immunogen design, pMHC library/ligand screening, affinity maturation, developability optimization, and functional characterization, with options to format as IgG, bispecifics, or CAR constructs.
Key Features / Benefits
- pMHC‑focused discovery platforms and immunogen design
- High‑specificity screening and affinity maturation for epitope‑restricted binding
- Developability profiling and humanization; multiple output formats (IgG, Bi‑specific, CAR)
- Functional validation (binding, signaling, cytotoxicity) and liability assessment
Relevant Applications
- Therapeutic programs requiring intracellular‑antigen targeting via pMHC
- Bispecific or CAR adaptor concepts leveraging TCR‑like specificity
- Preclinical candidate nomination with antibody‑class manufacturability
