IR‑Based Polymorph Screening Service
NGK Corporation offers the world’s first IR‑based polymorph screening service utilizing its proprietary infrared radiation technology. By selectively exciting specific molecular vibrations, this approach provides a novel screening pathway beyond conventional methods. This service enhances the likelihood of discovering previously unknown crystalline forms, aiming to contribute to our clients’ pharmaceutical development.
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Our IR based polymorph screening service is designed to identify crystalline polymorphs that are difficult to detect using conventional methods. It complements, rather than replaces, existing polymorph screening strategies.
The key concept underlying our service is that functional groups exhibit specific IR absorption bands, and excitation at the corresponding wavenumbers selectively activates their vibrational states. Based on this concept, we hypothesize that continuous, selective excitation of specific functional group vibrations may influence intermolecular interactions and molecular orientation.
Our unique equipment enables such excitation, potentially leading to differences in nucleation behavior and crystal growth, and thereby increasing the likelihood of discovering previously unknown crystalline forms.
Advancing crystal polymorph screening with infrared approaches
Monday, July 6 at 15:00 BST | 16:00 CEST | 10:00 EDT | 07:00 PDT
Identifying and controlling crystal polymorphism remains a critical challenge in pharmaceutical development, with implications for stability, bioavailability, and manufacturability.
In this SelectScience® webinar, NGK Corporation introduces a novel infrared-based screening approach designed to uncover previously undetected crystalline forms and complement existing polymorph screening workflows. Through case studies, attendees will explore how this technique can strengthen risk assessment and support more robust drug development.
An invited lecture from Professor Etsuo Yonemochi, School of Pharmacy at Narita, International University of Health and Welfare, will provide deeper insight into crystal morphology, examining how crystallization conditions influence crystal habit and how these characteristics impact dissolution, wettability, and downstream processing.
