Harrick ConcentratIR2™ Multiple Reflection ATR
Highly sensitive analysis of microvolume liquid samples by multiple-reflection ATR.
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The ConcentratIR2™ is a miniature multiple-reflection ATR accessory, compatible with the smaller FTIR sample compartments. Designed for micro-volume liquid samples, it features interchangeable diamond and silicon ATR sampling plates. Both ATR configurations consist of a thin disk of silicon or diamond that is optically contacted to a special ZnSe optic. The silicon configuration has eleven internal reflections with a nominal incident angle of 30° and is suitable for use from 4000 cm⁻¹ to 650 cm⁻¹. The diamond ATR has ten internal reflections with a nominal incident angle of 45° and an approximate wavelength range from 4000 cm⁻¹ to 550 cm⁻¹.
Features
- Pre-aligned for easy start-up.
- Rapid purging.
- Little or no sample preparation.
- Only 10 µl of sample required.
- Easy clean up between samples.
- Durable and sensitive ATR elements.
- Si with a nominal incident angle of 30° and eleven reflections.
- Extended Si with a nominal incident angle of 30° and twenty-three reflections.
- Diamond with a nominal incident angle of 45° and ten reflections.
- Optional liquid cells available.
- Ambient flow cells with Luer Lock or Swagelok™ fittings.
- Heated trough and flow cells for operation to 200° C.
Proving infrared spectroscopy workflows for GLP-1 agonist medications using the Harrick ConcentratIR2
Discover how the Harrick ConcentratIR2™ enables clear resolution of amide bands in model pharmaceutical peptides such as ziconotide, calcitonin, and leuprolide acetate at concentrations that are relevant for early-stage formulation and quality control. These peptides act as structural and analytical analogs for GLP-1-type drugs, aiding in the establishment of infrared spectroscopy workflows for evaluating purity, stability, and folding in peptide-based therapeutics.
