Gyrolab® Bioaffy™ 4000 HC Assay Toolbox
Gyrolab® Assay Toolbox with 4000 nL sample volume for development of HCP assays with the components of ready-to-use HCP Kits.
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Gyrolab® Bioaffy™ 4000 HC Assay Toolbox provides support for users who wish to develop assays with process-specific reagents based on components of the ready-to-use Gyrolab kits. Gyrolab Bioaffy 4000 HC Assay Toolbox includes Gyrolab Bioaffy 4000 HC disc (96 data points), wash buffers, sample dilution buffer, plates, foils and instructions for use. As the toolbox has been designed to enable the development of assays with your own reagents, additional optimization involving choice of sample dilution buffers and/or other components may be required depending on the nature of the assay.
Accelerate throughput in therapeutic antibody development with an improved generic PK assay
The development of recombinant IgG therapeutic drugs is challenging and often involves several candidates per program together with reagent selection for assay development. In addition, the safety and toxicology parameters of lead candidates must be evaluated in two pre-clinical species, such as mouse and cynomolgus monkey (cyno). Sample volumes may be limited, and analyte levels can vary greatly. The Gyrolab® Generic PK Kit was developed to meet these requirements to determine therapeutic levels in studies throughout the early and pre-clinical development of recombinant human intact antibodies of different IgG subclasses in serum matrices from a range of species. Further development has led to a second-generation kit, Gyrolab 2G Generic PK Kit. In this application note, Gyros Protein Technologies highlights the improvements achieved, including the increased dynamic range and the flexibility in dynamic range enabled with the option of using Gyrolab Bioaffy™ 1000 HC CD or other CD sizes including the Gyrolab Bioaffy 4000 HC CD. These benefits will help to streamline workflows by reducing the need for re-analysis when analyzing study samples with a wide range of analyte concentrations.
How immunoassay innovation has expanded the biotherapeutic development toolbox
Experts share how commitment to bioanalytical innovation and quality has enabled success in biotherapeutic development
