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Bio-Based Acetonitrile Gradient Grade for HPLC, LiChrosolv

BioRenewable, gradient grade for liquid chromatography LiChrosolv® Reag. Ph Eur

Merck

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Description

The First Bio-Based HPLC Acetonitrile on the Market — Built to Your Existing Specification.

Certified bio-carbon content. Identical gradient grade performance. No method redevelopment required.

Acetonitrile is the most widely used solvent in reversed-phase HPLC, and a significant contributor to a chromatography lab's Scope 3 CO₂ emissions across its full lifecycle.

LiChrosolv® BioRenewable Acetonitrile Gradient Grade is the first bio-based acetonitrile available for HPLC workflows. Derived from certified biomass feedstock and meeting the identical specification as the corresponding fossil-based grade, it delivers a direct, verifiable reduction in solvent-associated emissions — with no impact on your analytical workflow.

Features and Benefits

Biomass-derived. Chromatographically equivalent. Compliance-ready.

  • Bio-based, certified bio-carbon content:
    • Reduction in laboratory Scope 3 emissions.
    • Confidence that the methanol genuinely is derived from bio-based feedstock.
  • Identical specification to fossil-based grade:
    • Qualifies as a true drop-in replacement — no method redevelopment.
  • Gradient grade:
    • Purpose-formulated to reduce the gradient effect during separation, providing optimal baseline consistency and accuracy in gradient elution workflows.
  • Aligned with 12 Principles of Greener Chemistry:
    • Documented compliance with use of Renewable Feedstocks — auditable, traceable sustainability claims that hold up under procurement and regulatory scrutiny.

Switch Without Compromise

Brochures

Product brochuresSeparations

Bio-based HPLC solvents

Explore Merck MilliporeSigma’s range of bio-based HPLC solvents, including acetonitrile, methanol, and ethanol, designed to deliver the same chromatographic performance as conventional solvents while reducing reliance on fossil-based feedstocks. The solvents are compatible with existing HPLC and LC-MS workflows and offer verified sustainability benefits through bio-carbon content certification and reduced CO₂ emissions.

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Resource type: Product brochure
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Read time: 2 mins

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