Bio-Based Acetonitrile Gradient Grade for HPLC, LiChrosolv
BioRenewable, gradient grade for liquid chromatography LiChrosolv® Reag. Ph Eur

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The First Bio-Based HPLC Acetonitrile on the Market — Built to Your Existing Specification.
Certified bio-carbon content. Identical gradient grade performance. No method redevelopment required.
Acetonitrile is the most widely used solvent in reversed-phase HPLC, and a significant contributor to a chromatography lab's Scope 3 CO₂ emissions across its full lifecycle.
LiChrosolv® BioRenewable Acetonitrile Gradient Grade is the first bio-based acetonitrile available for HPLC workflows. Derived from certified biomass feedstock and meeting the identical specification as the corresponding fossil-based grade, it delivers a direct, verifiable reduction in solvent-associated emissions — with no impact on your analytical workflow.
Features and Benefits
Biomass-derived. Chromatographically equivalent. Compliance-ready.
- Bio-based, certified bio-carbon content:
- Reduction in laboratory Scope 3 emissions.
- Confidence that the methanol genuinely is derived from bio-based feedstock.
- Identical specification to fossil-based grade:
- Qualifies as a true drop-in replacement — no method redevelopment.
- Gradient grade:
- Purpose-formulated to reduce the gradient effect during separation, providing optimal baseline consistency and accuracy in gradient elution workflows.
- Aligned with 12 Principles of Greener Chemistry:
- Documented compliance with use of Renewable Feedstocks — auditable, traceable sustainability claims that hold up under procurement and regulatory scrutiny.
Switch Without Compromise
Brochures
Bio-based HPLC solvents
Explore Merck MilliporeSigma’s range of bio-based HPLC solvents, including acetonitrile, methanol, and ethanol, designed to deliver the same chromatographic performance as conventional solvents while reducing reliance on fossil-based feedstocks. The solvents are compatible with existing HPLC and LC-MS workflows and offer verified sustainability benefits through bio-carbon content certification and reduced CO₂ emissions.
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