Agilent 5977B GC/MSD

With increased price on the helium (He) market, laboratories are exploring the option of hydrogen (H2 ) carrier gas. Since hydrogen is a reactive gas, hydrogenation and dechlorination reactions can and do occur in the mass spectrometer electron ionization (EI) source. Here, Agilent Technologies presents a newly designed extractor source for the Agilent 5977B Inert Plus GC/MSD and Agilent 7000D/E Inert Plus triple quadrupole GC/MS systems and explains how it can address these hydrogen-related issues.

Gas chromatography/mass spectrometry (GC/MS) is integral to the analysis of semivolatile organic compounds (SVOCs). Recent pressure on the helium (He) supply has required organizations to actively investigate hydrogen (H2) carrier gas. Here, Agilent Technologies presents the Agilent HydroInert source and explains how it retains the ability to analyze a wide calibration range and meets the U.S. Environmental Protection Agency (EPA) method 8270 calibration criteria when using H2 carrier gas.

Instrument downtime, quality data, sample reruns, and data reviews are just some of the challenges associated with turnaround times that are critical to your business and reputation. Here, Agilent Technologies presents the Agilent 5977C GC/MSD, which aims to provide robust, day-in, day-out performance so you can focus your time on things that add value to your lab.

Lipidomics is a powerful technique for understanding biological systems and integral in a variety of research areas, including agriculture, clinical research and pharmaceuticals. In this application note, Agilent Technologies highlights some of its available solutions for lipidomics workflows, including GC/MS and LC/MS instrumentation. Download the full brochure to learn more about:

• The challenges of lipid separation
• Lipidomics tools for a variety of applications
• Lipid identification

Mutagenic impurities in APIs and drug products pose a significant risk to health and safety – even in small quantities – and thus are a major concern for drug manufacturers. In this application guide, Agilent Technologies provides an overview of recent regulatory action regarding nitrosamine impurities and outlines a complete workflow solution for the accurate detection and quantification of mutagenic impurities in APIs and drug products.

In this case study, Agilent describes the process of helping Eurofins Scientific boost productivity for environmental testing, to help them become an international life sciences company that provides a range of analytical testing services.

The 5977B GC/MSD System by Agilent builds on a long track record of innovation, bringing together the technologies of one of the industry’s best GC and MS systems. This case study details its origins in Eurofins Scientific, and how its design lends itself towards high efficiency and profitability.

In this application note, the Agilent QuickProbe, a direct insertion sampling device for GC/MS, is evaluated for the screening of nonextracted food samples. Foods analysis benefits from fast screening because it quickly identifies samples that are suspect and require further investigation.

An Agilent 8890 Gas Chromatograph (GC) configured with a flame ionization detector (FID) and a mass spectrometric detector (MSD) was used for the analysis of USP <467> residual solvents of Class 1, Class 2, and Class 3. There were 52 compounds with low boiling points introduced by an Agilent 7697A headspace sampler onto a DB-624 column, while 10 compounds with relatively high boiling points were introduced by the automatic liquid sampler onto a DB-WAX column. A purged two-way capillary flow technology (CFT) device was used to split the sample 1:1 onto FID and MSD.

In this application note, a HJ/T 400-2007 was used to determine the concentration of volatile organic compounds (VOCs) in the cabins of vehicles. A method is presented for their analysis using an Agilent 8890 GC/5977B MSD and a Markes' TD 100-xr automated thermal desorption (TD) system.

This video illustrates how QuickProbe and MS can identify compounds in a mixture, without sample preparation, in under a minute. QucikProbe contains Agilent's new sample introduction technology that is designed to provide rapid heating in the inlet coupled to a short separation column.

This video introduces the Jet-Clean Self-Cleaning Ion Source, a technology that allows operation for months without having to clean the source. This is designed to improve sensitivity, improve peak-shape, and prevent continuous recalibration.

The Scientists’ Choice Award for Life Sciences Video of the Year was awarded to Dr. Adam P. Rosebrock, Assistant Professor of Pathology and Member, Cancer Center, Stony Brook School of Medicine. The winning video, first published on The Scientists’ Channel, details Rosebrock’s work towards developing new assays using the latest mass spectrometry technology from Agilent Technologies to advance the field of small molecule metabolomics.

Find out more about Dr. Adam Rosebrock on The Scientists' Channel >>