Product News: Waters Introduces New Synapt G2 with Greater Power, Versatility and Speed Than Any Other High-End Mass Spectrometer

01 Jun 2009

Waters Corporation announced today the introduction of a powerful next-generation, high performance, mass spectrometer, the Waters SYNAPT G2 System. Taking qualitative and quantitative quadrupole time-of-flight mass spectrometry to new heights, the SYNAPT G2 system features new QuanTof and enhanced High Definition MS technologies intended to accelerate scientists toward their research goals.

The SYNAPT G2 System provides researchers with intuitive operation, application flexibility, and a totally new level of performance for biopharmaceutical, metabolite identification, metabonomics, proteomics, biomarker studies, and food and environmental applications. Waters introduced the SYNAPT G2 System at the 57th American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics in Philadelphia, PA.

The SYNAPT G2 System is capable of outstanding qualitative and quantitative performance for both MS and the elevated data acquisition rates of SYNAPT G2 HDMS analysis. For scientists this means performance in excess of 40,000 FWHM resolution, class-leading sensitivity, a data acquisition rate of 20 spectra/second, exact mass (1 ppm RMS) information and a dynamic range of up to five orders of magnitude. When paired with Waters ACQUITY UltraPerformance LC (UPLC) technology, Waters SYNAPT G2 Mass Spectrometer makes maximum use of the power and speed of UPLC outclassing all other LC/MS and LC/MS/MS systems.

Waters is expecting to deliver the first SYNAPT G2 units during the fourth quarter of 2009.

With the SYNAPT G2 System, scientists can make new discoveries and sound decisions based on the comprehensive, accurate and precise data that they can obtain from highly complex samples in just a single analytical run and at unprecedented speed.

Says Professor James Scrivens of the University of Warwick, "Incremental improvements in instrument performance are important drivers for advancing MS-based studies, but it's the combination of SYNAPT G2's high resolution oa-TOF technology, wide quantitative dynamic range and enhanced (high-efficiency) ion mobility resolution that is truly game-changing."

"The launch of SYNAPT G2 is a significant event because it represents both a major leap forward in MS technology ... and a huge new opportunity for the worldwide research community attempting to solve fundamental problems at the molecular level," says Brian Smith, Vice President, Mass Spectrometry Business Operations, Waters Division. He continued, "We're confident that the SYNAPT G2 will displace generic QTof and electrostatic ion trap systems as the de facto choice in high-end MS instrumentation."

Game-Changing Performance by Design

The SYNAPT G2 System features new QuanTof technology that combines an innovative high field pusher and dual stage reflectron with a novel ion detection system in an optimised, folded, TOF geometry. Together these features provide a new dimension of high resolution, exact mass and quantitative performance uniquely available at acquisition rates that are compatible with UPLC separations. No longer do scientists have to compromise mass resolution when they want chromatographic resolution and the benefits of high speed, selectivity, and specificity.

QuanTof's high field pusher and dual-stage reflectron reduces ion turnaround times associated with pre-push kinetic energy spread while its dual-stage reflectron improves focusing of high energy ions. As a result QuanTof technology provides the highest levels of comprehensive TOF performance available.

SYNAPT G2's novel ion detection system combines an ultra-fast electron multiplier with hybrid ADC detector electronics to provide outstanding qualitative and quantitative performance for both MS for the elevated data acquisition rates of HDMS analysis.

Integrated second-generation Triwave Technology, the ion mobility resolving power of the Synapt G2, is up to four times higher than the original SYNAPT system. This means scientists can separate similar sample components based on size, charge, mass, and shape - better than ever before and identify sample components that might have remained invisible to them until now. Moreover, QuanTof technology provides facile exact mass measurement and enhanced dynamic range for IMS/MS experiments, resulting in the highest coverage and confidence for novel discovery analyses.

With new DriftScope Mobility Environment Software (v2.1), the Synapt G2 comprehensively detects components, reveals new or subtle features in the data, and provides more efficient data processing workflows such as the measurement of a compound's collisional cross section (shape). With this capability scientists can make new discoveries while significantly reducing the time required to deliver business and research-critical information.

Engineered to Simplify the Process of Producing Analytical Results

The SYNAPT G2 incorporates the design philosophy of Engineered Simplicity that is a hallmark of Waters benchtop Xevo mass spectrometers and the first time Waters has introduced the design components into a versatile high-end research-grade mass spectrometry platform. These features - including IntelliStart technology which calibrates and prepares the instrument for operation while continually monitoring its performance - automate set-up procedures, minimize the opportunity for human error, and make the mass spectrometer more 'accessible' to those who may be new to mass spectrometry yet who need to generate high-quality results consistently.

Versatility and Flexibility

Finally, Waters offers a choice of UPLC inlet technologies and universal ion sources for the SYNAPT G2 System to maximize the number of experimental options and research applications. These comprise the nanoACQUITY UPLC? and TRIZAIC UPLC inlets and ion sources including: electrospray (ESI), nanoflow ESI, atmospheric chemical ionization (APCi), combined ESI/APCi (ESCi), atmospheric solids analysis probe (ASAP), and atmospheric pressure gas chromatography (APGC). The same ion source options are also compatible with the Waters Xevo TQ and Xevo QTof mass spectrometers.

The interchangeable design of the APGC source for the SYNAPT G2 System allows scientists to perform GC/MS and LC/MS experiments on the same instrument. No longer do laboratories have to dedicate separate mass spectrometers for either LC/MS/MS or GC/MS/MS work.

Waters also offers a high performance, exchangeable MALDI source for the SYNAPT G2 system with broad applications. For example, by combining MALDI with ion mobility separations, Waters High Definition Imaging MALDI (HDI MALDI) solution enables researchers to better determine the localization of metabolites and active drug compounds in tissue samples.

Waters offers a variety of general-purpose and specialized Applications Managers for its MassLynx MS software that allows the Synapt G2 to perform a multitude of tasks including screening, deconvolution, identification, target quantification, qualitative and quantitative profiling and characterization - and transform acquired data into useable results.

The Platform for Today. The Springboard for Tomorrow.

The Synapt G2 product family offers laboratories a choice of systems configured for the research needs of today as well as the future. In addition to the Synapt G2 with full HDMS capabilities, scientists have a choice of HDMS-ready products including the Synapt G2 MS and MALDI Synapt G2 MS that can be upgraded on site to maximize the full potential of second-generation HDMS functionality.

A Tradition of Innovation in Time-of-Flight Mass Spectrometry

Waters put quadrupole time-of-flight technology on the map in 1996 with the introduction of the first commercially-available Q-Tof system. With the introduction of the SYNAPT HDMS System in 2006, Waters incorporated new ion mobility technology into a quadrupole time-of-flight mass spectrometer for the very first time. At Pittcon '07 the system was awarded the Editors Gold Award for best new product. It is now being employed by some of the world's most prestigious universities and research institutes including the University of Cambridge, Imperial College London, Oxford University, University of Warwick, University of Leeds, University of California Davis, University of California Los Angeles, Duke University, Northeastern University, Rockefeller University, Van Andel Institute, and Vanderbilt University.

The Synapt G2 system demonstrates the commitment of Waters to always expand the research benefits of mass spectrometry.