Roche and PSS Sign Agreement to Develop a Fully Automated Workflow Solution for Next-Generation Sequencing Platforms

21 Dec 2012

Roche and Precision System Science, Co., Ltd (PSS) have announced the signing of an exclusive agreement to develop and manufacture a fully automated emulsion PCR instrument for Roche’s portfolio of next-generation sequencing platforms. It is intended to support Roche’s GS Junior and GS FLX+ systems as well as the sequencing platforms that Roche is currently developing.

Until now, upfront preparation of genomic samples has been a time-consuming and complicated manual process within the sequencing workflow. The new instrument will be designed to streamline the sample preparation workflow by automating the entire emulsion PCR process thereby reducing the total hands-on time from several hours to a few minutes.

“This partnership aims to address one of the key needs of sequencing customers,” said Dan Zabrowski, Head of Roche Applied Science. “The automated solution will not only improve the efficiency of laboratory workflows, but also increase the reproducibility of results by eliminating manual workload. This development program has made great progress over the last year, and we are looking forward to working with PSS because they offer outstanding expertise and have a strong track record in developing fully automated solutions.”

“We are delighted that PSS and Roche are expanding their long-standing relationship in automated DNA extraction to the challenging field of DNA sequencing,” said Hideji Tajima, President of PSS. “Preparing samples for sequencing is a complex, high-skill process that continues to hamper broader use of the technology. We believe that together PSS and Roche will be able to develop an automated instrument that helps overcome this obstacle and promote greater use of advanced sequencing systems.”

The agreement builds on a long-term reciprocal relationship between Roche and PSS. The two companies first started to collaborate on automated DNA extraction fifteen years ago, a partnership that resulted in the successful development and marketing of nucleic acid purification products.

GS Junior System

The power of next-gen sequencing in your hands. The GS Junior System brings the power of 454 Sequencing Systems directly to the laboratory benchtop. Get comprehensive genome coverage with long 400 bp sequencing reads and quickly proceed from DNA to discovery with fast sequencing runs and straightforward data analysis on the attendant computer.GS Junior System Features: Powered by proven technology: Uses GS Junior Titanium chemistry to deliver high-quality, bioinformatics-friendly, long read data Fits in your lab: Small instrument size, along with low entry and operating costs, enables labs with limited budget and infrastructure to take advantage of next gen sequencing Easy to use: Manageable data size allows processing and analysis right on the attendant computer without the need for specialized computing or network infrastructures Point-and-click data analysis: Includes the GS Data Analysis Software for de novo assembly, reference mapping and amplicon variant analysis Applications: Amplicon Sequencing: Targeted sequencing of 10's - 100's of samples and loci Sequence Capture: Targeted sequencing of custom array regions Whole Genome Sequencing: De novo sequencing and resequencing of microbial organisms (bacteria, fungi, viruses) Metagenomics: Characterization of complex environmental samples; pathogen discovery Transcriptome Sequencing: Full-length sequencing and de novo assembly of transcripts

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GS FLX+ System

Roche

Now delivering sequencing reads up to 1,000 bp in length! The GS FLX+ System features the unique combination of long reads, exceptional accuracy and high-throughput, making the system well suited for larger genomic projects. The GS FLX System has been at the heart of key breakthrough genomic discoveries and over 1,000 peer-reviewed publications to date.Advancements in sequencing chemistry, instrumentation and software offer the latest improvements in GS FLX System performance, with read lengths up to 1 kb. Available as an on-site instrument upgrade or new instrument, the GS FLX+ System is designed for use with both the new long-read Sequencing Kit XL+ and existing Sequencing Kit XLR70.GS FLX+ System Features: True capillary sequencing-like read lengths: Continuous development of the GS FLX Titanium chemistry now offers read lengths up to 1 kb Flexible sequencing formats: Broad selection of gaskets and Multiplex Identifiers (MIDs) enables efficient use of sequencing runs Point-and-click data analysis: Included GS Data Analysis Software for de novo assembly, reference mapping and amplicon variant analysis. Applications: Whole Genome Sequencing: De novo sequencing of large, complex organisms or multiple bacterial genomes in a single run Transcriptome Sequencing: Full-length de novo sequencing and assembly of complex organisms Amplicon Sequencing: High-throughput sequencing of 100s to 1,000s of samples and loci Sequence Capture: Targeted resequencing of whole exomes or large capture regions Metagenomics: Characterization of complex environmental samples; pathogen discovery

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Roche and PSS Sign Agreement to Develop a Fully Automated Workflow Solution for Next-Generation Sequencing Platforms