First Deals for High-Speed Screening of Ion Channel Drug
13 May 2014
Sophion Bioscience, part of Biolin Scientific, has received its first purchase orders for its new high throughput screening platform from leading pharma companies. The Sophion Qube™ measures the effect of potential new drug candidates directly on ion channels in living cells. By a unique combination of high quality recordings and high throughput, the Sophion Qube™ can boost the productivity of the first phases of ion channel drug discovery dramatically.
Qube™ is a 384-channel automatic patch clamp system that delivers ion channel data at an unprecedented throughput. At full integration into an existing screening line, Sophion Qube™ has the capacity to test more than 30,000 compounds in 24 hours. For up to 4 hours unattended operations, Sophion Qube™ is also available as a stand-alone system.
Sophion Qube™ is designed to reduce development time of drugs targeting ion channels, for indications like pain, epilepsy, bipolar disorder, depression and cystic fibrosis.
Morten Sunesen, VP of Drug Discovery Systems at Biolin Scientific, commented: "I am very happy to see that the most prestigious ion-channel laboratories in the world have chosen Sophion Qube™. It’s solid proof of our concept of uniting manual patch clamp quality with high throughput. Sophion Qube™ delivers a torrent of information for characterizing ion channels. Instead of screening on secondary information, we’re getting direct measurement at the point of action. That’s highly valuable for an evidence-based approach in drug discovery, and can greatly enhance the way ion channel drug discovery works”.
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Qube High Throughput Screening System
Sophion BioscienceThe Qube is Sophion's next generation high-throughput system for ion channel screening, intended for use in laboratories with a need for thousands of data points per day. The Qube finally bridges the gap between high-throughput and high quality in ion channel assays.The Qube can be used for primary and secondary screening of any ion channel of interest. Sophion's vast experience with planar patch clamp from the QPatch products has been utilized to create gigaseal recording substrates and flow channels for liquid exchange in the Qube measurement plates. With 384 parallel measurement sites and as little as 10-15 minutes per plate run, the Qube enables testing more than 1500 compounds in a single hour. With full automation features - a plate stacker and cell preparation unit - for unattended operation, the system provides walk-away time, which the scientist can use for other important tasks. The Qube is easy to operate with user-friendly software for experiment setup, automated data analysis and data export. Features: Throughput of over 10,000 compounds tested per day 384 simultaneous recordings in whole-cell patch clamp configuration 384 parallel amplifiers for high-quality patch clamp recordings Gigaseal resistances in recordings Excellent voltage clamp Excellent liquid exchange for multiple compound additions Cell membrane parameter compensations 384 pipettes with exchangeable tips Plate recording time approx. 15 minutes, for simplest assay Single-hole recordings (single-cell patch clamp) Multi-hole recordings (multi-cell patch clamp with 10 cells per well) Full automation for maximal walk-away time Cell preparation station Plate stacker unit User friendly software for data analysis and experiment setup