Product News: Defined & controllable extracellular matrix for cell culture

26 Aug 2021

Biochemically defined and animal-free - Mussel Adhesive Protein based matrix (MAPtrix™) from AMSBIO provides a highly defined and controllable recombinant extracellular matrix (ECM) for cell culture, which can be tailored to the specific needs of particular cell types.

Low cost and ready-to-use - MAPtrix™ produces a reliable and reproducible protein coating on a wide variety of surfaces including glass, plastic and biological surfaces. Used as a replacement for traditional basement membrane extracts in drug delivery, surface-modified medical device, stem cell and tissue engineering scaffold applications - MAPtrix™ delivers superior cell plating efficiency, improved cell morphology and enhanced cell proliferation.

Mussel Adhesive Protein is a highly desirable substrate for use in a variety of biological and medical applications because of its strong wet adhesive, non-toxic, biodegradable and low immunogenic properties.

MAPtrix™ technology works by incorporating small individual motifs from ECM proteins into recombinant proteins with a backbone of Mussel Adhesive Protein to attach to the substrate, thereby presenting the ECM motif for cultured cells to attach to. Incorporating mix-and-match genetically incorporated bioactive peptides - MAPtrix™ provides an in-vivo-like surface structure, that mimics the native extracellular environment, enabling the maintenance of cells under serum and feeder-free conditions.

AMSBIO also offer MAPtrix™ Screen arrays to help scientists to screen a range of ECM motifs to find which ones their cells will adhere to. They can then use these motifs to tailor a defined microenvironment in 2D, or combine the MAPtrix biomimetic with a Polyethylene glycol (PEG) crosslinker to form a hydrogel (MAPtrix™ Hygel) for 3D cell culture.

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