Biomarkers are biological molecules - for example, cells, proteins, hormones, metabolites or genes - that can be measured to identify a biological state. This makes their study of particular interest for disease pathogenesis, with possible applications in diagnosis, prognosis, as well as in drug discovery and development for monitoring the effects of treatments.
The search for novel biomarkers holds potential for earlier and less invasive disease diagnosis, for example through liquid biopsies, and is also a key focus for patient stratification and precision medicine approaches. With a wide range of potential biomarkers, numerous laboratory techniques play a role in biomarker research. Here, we look at some of the latest technologies, including multiplex assay, ELISA, immunofluorescence imaging, liquid chromatography, and proteomics and genomic approaches, and the researchers advancing this field.
Dr. Jochen Schwenk, KTH Royal Institute of Technology, discusses how bead-based affinity proteomics using Luminex xMAP® technology is enabling researchers to map the entire human proteome.
Learn how Bertin's calcitonin gene-related peptide (CGRP) ELISA kit provides reliable measurement of CGRP in human plasma, and why this biomarker is studied in the context of patient stratification.
Discover why PharmaFluidics’ micro Pillar Array Columns (µPAC™) are suitable for bottom-up proteomics, demonstrating the required lifetime as well as resilience for challenging samples.
This download outlines a method for using BERTHOLD TECHNOLOGIES' TriStar² S LB 942 Multimode Microplate Reader with the Promega NanoBRET™ Protein:Protein Interaction System.
This study by Akoya Biosciences shows a complete workflow for spatially resolved, tissue-based biomarker discovery to elucidate cellular heterogeneity in the tumor microenvironment.
Bio-Rad's Dr. Yan Wang, Reagent R&D, shares the approach her team has taken to develop useful, high-quality and easy-to-use genomics tools to streamline DNA and RNA expression analysis.
In this application note, discover a novel method to optimize quantification of RNA in archival material using the MMI CellCut system for the separation of morphologically different tissue areas.
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