Generation and rapid maturation of cortical layer V glutamatergic neurons from human iPSCs
8 August 2018
Numerous neurological and psychiatric disorders involve glutamatergic neurons specific to one or more of the six cortical layers. Death or malfunction of these specific neurons underlies disease pathophysiology and disrupts higher cognitive function. Study of these neurons may reveal the molecular mechanisms behind their vulnerability and enable development of more relevant disease models. Toward this goal, a protocol was developed to efficiently produce enriched cortical layer V glutamatergic neurons.