Thermo Fisher Scientific introduces sequential protein/DNA/RNA extraction kit

Thermo Fisher Scientific has introduced the Thermo Scientific™ Sequential Protein/DNA/RNA Extraction Kit, a sample preparation solution designed to enable the sequential extraction of protein, DNA and RNA from a single sample.

By allowing researchers to generate genomic and proteomic data from the same biological material, the kit helps address a common challenge in cancer and disease research, where samples are often limited and difficult to replace. As a result, researchers can more directly compare results from small or precious samples.

The kit is intended to support research workflows that seek to better understand the biological mechanisms underlying disease by connecting genetic variation, gene expression, and protein-level activity.

Purified protein is suitable for downstream mass spectrometry analysis, while extracted DNA and RNA are compatible with next-generation sequencing applications, enabling more direct comparison of molecular data generated from the same sample.

As research increasingly relies on small biopsies, rare cell populations, and other precious samples, the Sequential Protein/DNA/RNA Extraction Kit is designed to help researchers make more effective use of limited material while maintaining consistency across downstream analyses.

Key features include:

• Single-sample molecular analysis: Enables sequential extraction of protein, DNA and RNA, and protein from the same cell or tissue sample, helping researchers connect molecular signals across biological layers while making efficient use of limited material.
• Compatibility with downstream analysis: Produces purified DNA and RNA suitable for next-generation sequencing and protein suitable for mass spectrometry, supporting commonly used genomic and proteomic research workflows.
• Designed for limited and precious samples: Supports research involving small or difficult-to-replace samples, such as biopsies or rare cell populations, where dividing material across multiple workflows may not be feasible.

Dr. Osamu Ohara, Head of the Department of Applied Genomics, Biophysics and Clinical-omics, Kazusa DNA Research Institute, Japan, commented, “What I really loved about the Sequential Protein/DNA/RNA Extraction Kit is how the magnetic bead workflow let me easily recover proteins, RNA, and DNA in solution without any centrifugation, automate the entire process if I wanted to, and use the purified material immediately for downstream applications.”

For research use only. Not for use in diagnostic procedures.

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