Source BioScience Granted Exclusive Worldwide Licence by the Max Planck Institute to Commercialize the <em>C. elegans</em> and <em>Drosophila melanogaster</em> TransgeneOme Collections

The TransgenOme collections, developed by Dr Mihail Sarov at the Max Planck Institute of Molecular Cell Biology and Genetics, offer a novel opportunity for the exploration of protein function in Caenorhabditis elegans and Drosophila melanogaster.

The collection enhances the Source BioScience portfolio of genome-wide clone resources for use in this important model organism. In addition, the library offers unique applications to complement a wide scope of research. These include:

C. elegans TransgeneOme collection applications exclusively from Source BioScience:

• GFP-tag allows visualisation of protein localisation and expression levels in vivo in many cell types and of all life stages using live fluorescence microscopy or other methods for high-resolution in vivo imaging
• Affinity tags can be used for established methods of protein purification coupled with mass spectrometry for protein-protein interaction analysis
• Approach to map protein binding sites on DNA by tag-based chromatin immunoprecipitation, coupled with NGS (ChIP-Seq) - without the need to develop highly-specific antibodies

Drosophila TransgeneOme collection applications exclusively from Source BioScience:

• expression of tagged proteins under native control - enabling various in vivo applications
• systematic investigation of expression patterns and protein localisation at all developmental stages in different tissues, cell types and subcellular compartments
• identification of interaction partners by purification of protein complexes and subsequent mass spectrometry
• assessment of the extent and functional role of translational control of protein expression by comparing spatial expression data of mRNA with that of proteins

These resources are available on GenomeCUBE®, the interactive proprietary database, search engine and e-commerce tool and can be located by entering GenePair IDs, FlyBase IDs or gene symbols.