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Solutions for the Visualization and Analysis of Big Image Data in Life Sciences

ZEISS Research Microscopy Solutions

ZEISS and arivis AG partner to provide leading 3D imaging systems

5 Aug 2015
Chelsie Phillips
Temporary Editorial Assistant

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New microscopy technologies, such as light sheet fluorescence microscopy (LSFM) or clearing methods, allow the imaging of large samples at high resolution or high frame rates. ZEISS has teamed up with arivis AG to offer complete solutions from initial image acquisition to final results, designed to overcome common challenges in handling, processing, and analyzing multi-terabyte data sets.

arivis Vision4D is a modular software for handling multidimensional (3D+) images of nearly unlimited size. Users can easily import images generated with microscope systems such as ZEISS Lightsheet Z.1, and comfortably stitch and align single images into large comprehensive image stacks. This enables easy assessment and efficient analysis of, for example, high resolution brain mapping experiments or long-term observation of developmental processes in embryos. ZEISS is offering an integrated package worldwide, consisting of arivis Vision4D software and certified high performance computer hardware.

Moreover, arivis and ZEISS have developed 3Dxl Viewer, an integrated rendering module for the imaging software ZEISS ZEN (blue edition). It allows the handling of large 6D data sets acquired on ZEISS LSM 800 with Airyscan.

Current publications reflect how actively the scientific community has been tackling the challenge of big image data. Two recent review articles authored by Jeff Lichtman, Hanspeter Pfister, Nir Shavit, and Doug Richardson of Harvard University and the Massachusetts Institute of Technology (Lichtman et al., Nature Neuroscience, 2014; Richardson and Lichtman, Cell, 2015) explain the monumental task currently facing neuroscientists and other biologists attempting to image large intact tissues at micrometer resolution.

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Software PlatformsSoftware platforms are useful for various stages of laboratory experiments from data collection to data storage and processing. For instance lab software is available for system control, data management, data analysis and qualification / validation.Light MicroscopyLight microscopes or optical microscopes are used to visualize microscale objects under magnification, including cells, clinical specimens and materials. Lab equipment for light microscopy includes confocal microscopes, fluorescence microscopes, zoom and stereo microscopes. Microscope slides and imaging reagents are available for visualizing samples, as well as various microscope stages and incubators for large or temperature-sensitive samples. Find the best light microscopes in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.3D Imaging3D imaging technologies allow for the visualization and analysis of three-dimensional structures at high resolution. These systems are used in fields like molecular biology, material science, and medical diagnostics. 3D imaging can be applied to visualize cells, tissues, and organs, providing valuable insights into their structure and function. Browse our peer-reviewed product directory to find the best 3D imaging solutions, compare products, check reviews, and get pricing directly from manufacturers.Fluorescence MicroscopyFluorescence microscopy has become an essential tool in biology, as well as in materials science. The application of many fluorochromes has made it possible to identify cells and sub-microscopic cellular components with a high degree of specificity. Using multiple fluorescence labels, different probes can simultaneously identify several target molecules.MicroscopyMicroscopy is a technique used to observe small objects in detail, from cells to materials, using light or electron microscopes. It enables researchers to examine structures with high resolution, aiding in fields such as biology, medicine, and materials science. With advanced microscopy techniques, scientists can gain insights into cellular processes, tissue structures, and material properties. Explore the best microscopy solutions in our peer-reviewed product directory, compare products, read customer reviews, and get pricing directly from manufacturers.Software SolutionHigh Content ImagingHigh content imaging is a method combining two or more fluorescent microscopy experiments to identify substances that alter a cell’s phenotype in a desired manner. The process is adapted to multi-well plates and both the image acquisition and analysis are automated.

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