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Shimadzu Releases LC/MS/MS Method Package for Rapid Toxicology Screening for Several Classes of Toxicological Compounds

Shimadzu Corporation
16 Jun 2013
Sarah Thomas
Associate Editor

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Shimadzu has introduced a method package for rapid toxicology screening of 106 compounds. Featuring predetermined analytical conditions, including MRM transitions, LC separation conditions, retention times, spectral libraries, and report files, it enables researchers to rapidly implement a screening method for several classes of substances.

Developed in conjunction with forensic medicine and critical care researchers, Shimadzu’s LC/MS/MS Method Package for Rapid Toxicology Screening includes method parameters for 106 of the most important toxicological compounds, including drugs of abuse, pharmaceuticals, psychotropics, and hypnotics. It incorporates established calibration curves and uses diazepam d5 as an internal standard. As a result, this screening tool provides laboratories the ability to perform semi-quantitative analysis without purchasing dozens of costly standards. Target peaks are confirmed by comparison to the spectral library included in the method package.

Also included is an optimized sample preparation protocol for toxicology screening based on QuEChERS*. With this protocol, a total solution for toxicology screening from sample preparation to reporting is provided.

*QuEChERS (Quick, Easy, Cheap, Effective, Rugged, Safe) was developed by Anastassiades et al in 2003 as a sample preparation method for residual pesticide analysis in agricultural products.

Disclaimer: For Research Use Only. Not for Use in Diagnostic Procedures.

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Toxicology / Drugs of Abuse TestingToxicology and Drugs of Abuse Testing is the investigation into toxic and illegal substances found at the scene of a crime or from a suspect and / or victim associated with a scene of a crime. Analyzers, immunoassays and drugs of abuse test kits and presumptive test kits are an essential aspect of toxicology investigation.Drugs of AbuseA drug of abuse is a drug that has been taken for non-medical purposes. Such drugs can have mind-altering effects, with some causing dependence and addiction.QuEChERSPharmaceuticalsPharmaceuticals are medicinal drugs used in healthcare to diagnose, prevent, cure and treat illnesses. Pharmaceuticals that are excreted after use appear in wastewater and can have detrimental effects on the environment.ASMSThe American Society for Mass Spectrometry (ASMS) is an organization dedicated to advancing the science and application of mass spectrometry. ASMS supports professionals through events, publications, and research initiatives, promoting innovation in areas like proteomics, metabolomics, and environmental analysis. Forensic InvestigationForensic investigation is a diverse collection of scientific techniques and methods for the identification and characterization of chemicals relating to crime scene investigations.Forensic ToxicologyForensic toxicology is used to determine cause of death, drug use and contaminations. Toxicological evaluations are commonly used in analytical chemistry, clinical, life sciences and forensics.

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