Sartobind Q SingleSep^® nano: The Membrane Adsorber Featuring a 1ml Bed Volume

The compounds and drugs used for pharmaceutical and biotechnological research are extremely valuable. Consequently, it is important to keep their quantities for each test series as small as possible.

When scaling-up, it is particularly vital that conditions in the test phase be completely transferable to production scale. Sartorius Stedim Biotech is setting new standards in this area with the smallest scalable membrane adsorber capsule around: Sartobind Q SingleSep^® nano is the youngest and tiniest member of the Sartobind SingleSep family. With Sartobind Q SingleSep nano, you can transfer your manufacturing processes linearly from the lab to the production scale. Now, scaling up from several milliliter to 10,000-liter production volumes is no problem whatsoever.

Reduce Costs
The new membrane adsorber capsule is the perfect tool for polishing valuable proteins. The capsule can be used for the removal of viruses, DNA, host-cell proteins, protein A and endotoxins from pharmaceutical proteins such as monoclonal antibodies etc. Thanks to its low minimum volume, Sartobind Q SingleSep nano helps users save substantially, for example, on cost-intensive virus spiking studies, because they need less material and smaller quantities.

Minimal Volumes
Sartobind Q SingleSep nano features a cylindrical design and a bed volume of just one milliliter. As in large units, the feed solution is channeled through a 4 mm high bed equipped with a strong anion exchanger membrane. A uniform flow across the large frontal cylindrical surface (approx. 2.4 cm²) reduces backpressure. This feature additionally lets you scale-up direct to capsules and modules with several liters of bed volume. The recommended flow rate of 25-30 ml/min is 10 times higher compared to conventional column chromatography. Because it's so easy to use – Sartobind Q SingleSep nano can be installed like a filter – there's nothing that stands in the way of its quick use in the laboratory.