Residual solvents analysis for the pharmaceutical industry using the Agilent 8697 Headspace Sampler and 8850 GC-FID system

24 Oct 2025

Residual solvents left behind during API manufacturing pose a regulatory challenge for pharmaceutical producers, requiring precise monitoring to ensure product safety and compliance with USP <467> standards.

Discover how a headspace GC system delivers reliable detection, resolution, and quantitation of residual solvents using helium and hydrogen carrier gases, supporting accurate screening and limit testing in pharmaceutical workflows.

8697 Headspace Sampler

Agilent Technologies

Based on the flagship Agilent 8890 GC and 7697A headspace sampler, the Agilent 8697 headspace sampler is the first Agilent headspace sampler with integrated GC communication. That means you can manage your GC workflows from a single interface and spend more time on what matters.

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8850 GC System

Agilent Technologies

The single-channel Agilent 8850 Gas Chromatograph (GC) system combines the small footprint and compact oven of the Agilent 6850 GC with the same built-in intelligence and high performance of the 8890 GC. It was designed for energy efficiency and ease of maintainance to help laboratories meet their sustainability goals and lower their operating costs.

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Gas ChromatographyGas chromatography (GC) is an analytical technique used to separate and quantitate mixtures of small and volatile compounds. Gas chromatographs or GC systems include components such as GC columns, detectors, pumps and autosamplers. Choose from packed or capillary GC columns, flame ionization (FID), photoionization (PID) electron capture detectors and selective or non-selective detectors. Find the best gas chromatographs in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.Active PharmaceuticalsThe Active Pharmaceutical Ingredient (API) of a drug is the component that causes the direct effect of the product. The remaining inactive components are known as excipients.