Principle biopharmaceutical company introduces ActivityBase XE to improve screening efficiency

30 Jan 2007

IDBS today announces that long time ActivityBase user, Organon (Oss, The Netherlands and Newhouse, UK), has introduced the XE module into its Molecular Pharmacology departments in Oss and Newhouse. This follows a comprehensive pilot of XE and extensive collaboration with IDBS.

Organon incorporated the ActivityBase test management system in 2002, to improve efficiency in compound screening. Following the release of XE in September 2005, Organon sought to evaluate IDBS’ screening-specific module.

Dr Steven van Helden, Section Head for Screening and Technology at Organon, commented: “We have been very satisfied with our ActivityBase installation but constantly look for ways to improve efficiency within our screening process. As we recently introduced a new laboratory automation platform for in-vitro testing it was clear that there was also a desire to improve on our data processing. The attraction of the XE module was the ability to perform verification, analysis and visualisation within one environment. This greatly improves our workflow for High Throughput Screening, Hit Optimisation and Lead Optimisation.” Dr van Helden continued: “The designer element of XE, being linked to the context of the experiments, reduces the time and effort associated with template maintenance. This means we can spend more time analysing data, and less time developing analysis templates.”

Neil Kipling, CEO and founder of IDBS, added: “We have many thousands of ActivityBase users – most of whom are engaged in biological screening. The addition of XE to ActivityBase makes it even more applicable and useful to an organisation’s HTS program. Providing context around screening results promotes better understanding, which in turn supports better decision making.”

ActivityBase XE

IDBS

IDBS ActivityBase XE - Superior template design flexibility offers a revolutionary solution for enhancing high throughput screening data management ActivityBase XE delivers ultra high performance screening and flexible data visualization in one single working environment. Easy to use, flexible and intuitive The XE module for IDBS ActivityBase streamlines workflow and optimizes productivity. as well as support for traditional high throughput (HTS) analysis, the latest version of ActivityBase XE now supports high content screening (HCS) and multiplex screening methodologies.  IDBS ActivityBase XE allows screening scientists to: Capture, visualize, analyze, quality check and verify data within the same XE environment Rapidly analyze captured screening data and accelerate results calculations due to significantly faster data processing View experimental data with flexible and intuitive visualization not available in general spreadsheet packages Use manual or automatic mode to run large test sets, so data can be edited in real time or captured and analyzed as batch data in one run Apply 'free-form' plate format flexibility to perform a variety of assays on the same plate, such as single-point primary screens and dose response secondary screens Access the powerful XLfit math functionality to apply outstanding and reliable curve fitting to data Automatically exclude sample plates based on an association with a failed QC plate, or on criteria such as z-prime outside a predefined range

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