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PerkinElmer Highlights New Drug Discovery and Life Science Research Solutions at SBS 2011

PerkinElmer
26 Mar 2011
bridget bridget
Laboratory Director

Product news

At the Society for Biomolecular Sciences 2011 in Orlando, Florida, PerkinElmer, Inc., a global leader focused on the health and safety of people and the environment,will be showcasing several new drug discovery technologies and applications - including new products based on Alpha technology and a novel panel ofepigenetics-based detection reagents.

According to Martina Bielefeld-Sévigny, Ph.D., vice president and general manager, Drug Discovery and Research Reagent Solutions, Bio-discovery, PerkinElmer, “PerkinElmer provides researchers in drug discovery and life sciences with the ability to approach targets from multiple perspectives; to locate, detect and quantifytheir targets of interest, to analyze and understand them in wider physiological contexts. Our ability to deliver reagents, instruments, knowledge and services, helps advance research and drug discovery with the translational data and analysis to help lead to breakthrough insights.”

PerkinElmer's SBS offerings will include the Company's expanded epigenetic detection reagents specifically validated for drug discovery and life sciences research for disease states including cancer, neurodegenerative and metabolic disorders, as well as applications for stem cells and immunology.Additionally, PerkinElmer will also feature the EnSpire®Multimode Plate Reader with new optical label-free detection, the first and only benchtop detection platform to combine Corning®Epic®label-free technology and traditional labeled assays to accurately identify and characterize potential new therapeutic targets.This combination of labeled and label-free detection technologies providesresearchers with a more complete and insightful view of their cellular and biochemical interactions.

PerkinElmer’s new technologies and assay expansions on display at SBS Booth 701 include:

• EnSpire Multimode Plate Reader with label-free technology
• Expanded target class coverage for Epigenetics, cellular kinases and protein-protein interactions
• Expansion of the AlphaLISA®research assaysto over 100 no-wash biomarker kits for a variety of therapeutic areas including neurodegeneration, cancer and virology
• Operetta® High Content Imaging System with new PhenoLOGIC™, machine-learning technology for intuitive cell classification
• PerkinElmer’s epigenetic and post-DNA translational screening tools now cover nine different histone marks as well as p53, with more than 15 validated enzyme assays to help researchers discover novel drug compounds directed against several epigenetic enzymes, such as histone methyltransferases (HMTs), demethylases (HDMs), acetyltransferases (HATs) and deacetylases (HDACs).

Additional PerkinElmer products on display at SBS Booth 701 will include:

• FMT in vivo Imaging System
• Operetta®High Content Imaging System
• Columbus®Data Management Software
• Volocity®3D Imaging Software
• EnVision®Multilabel Plate Reader
• JANUS®Automated Workstation

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PerkinElmerCompany website

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Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Automation Supplies / AccessoriesAutomated accessories and consumables make lab processes fast, efficient and reliable. Useful automation accessories include microplate sealers, label printers and reagent reservoirs.Plate ProcessingAutomated plate processing is used in microplate technologies for high-throughput, speed and efficiency. Plate processing systems include microplate handlers for moving plates, heat sealers, stackers and carousels for storage, retrieval and delivery, microplate washers and piercers. Useful features of plate processors include walk-away automation, compatibility and easy integration with microplate systems.

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PerkinElmer Highlights New Drug Discovery and Life Science Research Solutions at SBS 2011