Oxford Gene Technology (OGT) Extends Its Chip^2™ Microarray Family

Oxford Gene Technology (OGT) has extended its Chip² family of ChIP on chip microarray products with the addition of four prokaryote species. These include Escherichia coli 0157, Salmonella typhimurium LT2, Salmonella typhimurium SL1344 and Streptomyces coelicolor and bring the total number of products in the family to five. Earlier in the year OGT launched its first product in the Chip² family, an E.coli K12 ChIP on chip microarray.

The Chip² microarrays can be used to identify the binding positions of global DNA-binding proteins, analyse changes in a particular protein’s binding under various environmental conditions, as a model system to further understand gene regulation or to reveal potential therapeutic targets against a prokaryotic species.

Each Chip² microarray is fabricated using OGT’s ink-jet in-situ synthesis (IJISS) platform and interrogates the genome of interest with a probe density of 22,000 oligonucleotide features. ChIP microarray data generated can then be analysed in relation to its relative gene position using an OGT developed ChIP browser, reducing the time taken to analyse the data.

Dr Mike Evans, Chief Executive of OGT, said: “The extension to the Chip² family of microarray products illustrates OGT’s commitment to progress its product development programme. Each additional Chip² product has been developed and validated by a leading scientist in the prokaryote field including Professor Jay Hinton from the Institute of Food Research, Norwich, UK; Professor Colin Smith, University of Surrey, UK and Professor Charles Penn, University of Birmingham, UK.”