New ultra-fast Nexera QX Multiplex LC-MS/MS system multiplies sample throughput to maximize productivity

21 Dec 2020
Meg Hicks
Student / Graduate

Shimadzu Scientific Instruments introduces the Nexera QX Multiplex LC-MS/MS system that uses multiple, alternating sample introduction streams for continuous operation of the mass spectrometer to significantly increase laboratory throughput and profitability.

Nexera QX Multiple Stream technology eliminates waiting for column equilibration and system flushing. Nexera SIL-40 UHPLC autosamplers, stream-dedicated injection valves and washing pumps deliver ultra-fast performance with ultra-low carryover.

The Nexera QX System adds multiple injection valves to the Nexera SIL-40 series autosampler, the industry standard for fast and clean injections. It also intelligently controls dedicated Nexera UHPLC pumps to automate flow line rinsing of each analytical stream to mitigate carryover from extreme samples.

Newly developed QX Solution software provides an automated single point of control for multiple UHPLC streams and the mass spectrometer for a multiplexed workflow. QX Solution simplifies valve switching, gradient control and injection timing and can execute automatic flushing from dedicated pumps to reduce autosampler and column carryover to a minimum. Specifically designed for the high-throughput laboratory, the system features the easy import of spreadsheet sample batches.

The Nexera QX system delivers industry-leading robustness, sensitivity and detection speeds with Shimadzu’s most powerful tandem mass spectrometer, the LCMS-8060NX triple quadrupole mass spectrometer.

The new IonFocus electrospray unit and newly designed ion guides deliver robust operation through reduced matrix effects and less contamination inside the instrument. This results in maximized uptime, superior data quality, and a more efficient analytical workflow.

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Nexera LC-40 series

Shimadzu has long been advancing the analytical performance of HPLC systems. At the same time, we recognize that overall efficiency depends not only on the performance of one instrument, but on the management of all devices within a lab. This realization leads us to now, a time in which AI capabilities have been incorporated to allow devices to detect and resolve issues automatically. In addition, lab management has ben integrated using the Internet of Things (IoT) and device networking, making it simple to review the status of instruments and optimize resource allocation. Building upon 40 years of experience in LC technology, the Nexera series is a family of HPLC systems that marries these AI and IoT enhancements to set new industry.

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Nexera HPLC System

Shimadzu's Nexera is a genuine all-around HPLC that enables various types of analysis including conventional LC, ultra fast LC and ultra high-pressure LC up to 130 MPa without compromising performance and data quality. The LC-30A Nexera delivers high-speed and high-resolution analysis without sacrificing basic performance parameters such as excellent precision, near-zero carryover, good linearity, stability and ruggedness. Offering these attributes enables Nexera to provide superior performance in various fields, covering high-resolution and high-speed separation, as well as high-sensitivity detection. Features of the Shimadzu LC-30A Nexera include: • New zero carryover• Absorbance detectors with excellent stability and sensitivity• Precise sample injection regardless of volume• Finest Reproducibility under Ultra-High Speed• Reduced otal analysis time• Large sample capacity for high throughput sample analysis

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