New Cell Culture Media Improves Transient Transfection Performance in Biopharmaceutical Research and Production
18 Sept 2013
The new portfolio of Thermo Scientific versatile animal-derived component-free (ADCF) and serum-free media enhances performance for transient transfection media and includes the Thermo Scientific HyCell TransFx-H for use with HEK293 cells and HyCell TransFx-C for use with CHO cell lines. In an internal study, HyCell TransFx media demonstrated high transfection efficiencies and viable post-transfection cell density. Most notably, these media demonstrated up to two-fold or higher increase in protein expression over other media products.
“As the industry leader with more than 40 years of cell culture experience, we have bioprocessing experts continuously developing innovative and superior cell culture media to enable our biopharmaceutical customers to meet the demand of high production levels and stringent timelines,” said Tariq Haq, senior global product manager for media at Thermo Fisher Scientific. “These nutrient rich media also eliminate the need to switch or supplement the medium. Our customers can expect to see significant productivity gains with fewer manufacturing runs in transient transfection processes.”
Thermo Fisher showcased its new HyCell TransFx media this week at the BioProcess International Conference and Exhibition, September 17-19, 2013, Hynes Convention Center, Booth # 611.
Thermo Scientific serum-free media products are manufactured to the highest quality standards in cGMP and ISO-compliant facilities. HyCell TransFx-H and TransFx-C are available in liquid form in 1L bottles and in 1 to 500L bioprocess containers. The media are also available as a powder in pack sizes to make 5 to 1000L media. Custom packaging specific to bioprocessing needs is available upon consultation with our technical experts.
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HyCell™ TransFx™-C Media
Thermo Fisher ScientificSupport transient transfection, growth, and expression of a variety of recombinant proteins in CHO cells with Thermo Scientific™ HyCell TransFx-C Media, a high-performing, animal-derived component-free cell culture media. HyCell TransFx-C media is a hydrolysate-free and regulatory-friendly Thermo Scientific ADCF™ cell culture media. Its versatility allows quick adaptation and supports excellent transfection, high viable cell density, and high productivity across a variety of CHO cell lines.HyCell TransFx-C media was developed through our Thermo Scientific Metabolic Pathway Design™ process to provide consistent performance and maximize process yields in transient transfection and expression of recombinant proteins. The HyCell TransFx-C media is extremely versatile and can be used with a variety of CHO cell lines in microliter volumes starting from 200µL to production-scale volumes in bioreactors.In addition to component traceability and regulatory-friendly animal-derived-component-free characteristics, HyCell TransFx-C media is manufactured in a cGMP- and ISO-compliant facility to provide a quality product for cell culture and bioprocessing applications.HyCell™ TransFx™-C Media Features: Defined hydrolosate-free ADCF cell culture media formulation. Supports transient transfection and growth of multiple CHO cell lines. Supports the transient expression of a variety of recombinant proteins. Same media for transient transfection and production. Developed through our Metabolic Pathway Design process for high transfection efficiency, high viable cell yields, and recombinant protein production. Component traceability. Manufactured under cGMP in ISO-compliant facility.
HyCell™ TransFx™-H Media
Thermo Fisher ScientificSupport transient transfection, growth, and expression of a variety of recombinant proteins in HEK293 cells with Thermo Scientific™ HyCell TransFx-H Media, a high-performining, animal-derived component-free cell culture media. HyCell TransFx-H media is a hydrolysate-free and regulatory-friendly Thermo Scientific ADCF™ cell culture media. Its versatility allows quick adaptation and supports excellent transfection, high viable cell density, and high productivity across a variety of HEK293 cell lines.HyCell TransFx-H media was developed through our Thermo Scientific Metabolic Pathway Design™ process to provide consistent performance and maximize proces yields in transient transfection and expression of recombinant proteins. HyCell TransFx-H media is extremely versatile and can be used with a variety of HEK293 cell lines in microliter volumes starting from 200µL to production-scale volumes in bioreactors.In addition to component traceability and regulatory-friendly animal-derived component-free characteristics, TransFx-H media is manufactured in a cGMP- and ISO-compliant facility to provide a quality product for cell culture and bioprocessing applications.HyCell™ TransFx™-H Media Features: Defined hydrolysate-free ADCF cell culture media formulation. Supports transient transfection and growth of multiple HEK293 cell lines. Supports the transient expression of a variety of recombinant proteins. Same media for transient transfection and production. Developed through our Metabolic Pathway Design process for high transfection efficiency, high viable cell yields, and recombinant protein production. Component traceability. Manufactured under cGMP in ISO-compliant facility.