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New applications for imaging and cytometry in drug discovery

Biostatus Limited
9 Sept 2008

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Biostatus will be presenting several new applications in flow cytometry with CyTRAK Orange and DRAQ5: circulating epithelial cell detection; circulating endothelial cell detection; human whole blood differential; human bone marrow differential; and a rat bone marrow differential. In addition, data published this year shows the effective use of DRAQ5 for in vitro toxicology in both primary hepatocytes and HepG2 cells. In one study DRAQ5 was used to report cell number, nuclei/DNA and (phospho)lipid vesicle formation.

Biostatus has launched two NEW CyGEL products: an improved standard formulation of CyGEL, that makes it easy to work with; and CyGEL Sustain for the addition of culture medium to permit live non-adherent cell imaging for several hours. As well as non-adherent cells CyGEL has been successfully used with zebrafish, protozoan parasites and helminthic worms.

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DRAQ5

Biostatus Limited

The proven far-red probe for live or fixed cells, spectrally compatible with UV / Vis-range fluors.

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Flow Cytometry / Cell CountingFlow cytometers are used to count, sort and examine multiple characteristics of cells. Other cell analysis equipment includes image cytometers, cell counters, fluorescence-activated cell sorters (FACS), magnetic-activated cell sorters (MACS), and a range of flow cytometry assay kits. Flow cytometers can reveal information on cell viability, cell proliferation, apoptosis and cell cycle progression, as well as identify cell populations and intracellular or cell-surface molecules. Additionally, some flow cytometers, known as FACS, have an additional sorting function after analysis. Cell counters and image cytometers count live and dead cell populations and can also conduct cell proliferation assays. Find the best flow cytometers, cell counters and cell sorters in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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New applications for imaging and cytometry in drug discovery