EMD Millipore Introduces Novel Clarisolve® Depth Filters that Deliver Unmatched Speed and Efficiency for Single-Stage Clarification of Pretreated Feed Streams
16 Sept 2013EMD Millipore, the Life Science division of Merck KGaA, Darmstadt, Germany, has introduced the Clarisolve® depth filter for single-stage clarification of pretreated feed streams. The Clarisolve® depth filter is a novel clarification device with a gradient density structure specifically designed to the particle size distributions of pretreated feed streams.
Delivering improved volumetric capacity and reduced turbidity over any currently available depth filtration technologies, Clarisolve® depth filters process pretreated feeds in a significantly reduced footprint without the need for the secondary stage of clarification. The use of Clarisolve® depth filters eliminates the need for centrifugation which enables implementation of a fully single-use process train, and also considerably reduces the pre-use flushing requirements. This technology was developed to address the shortcomings of traditional downstream clarification approaches when processing high cell density and high-product titer cell cultures.
”Until now, higher titers coming from upstream bioreactors have posed a challenge to conventional approaches to clarification,” described Vin Donovan, Vice President of Biopharm Process Solutions, EMD Millipore. “With Clarisolve® depth filters, our customers can now take full advantage of high density pretreated feed streams and improve overall process economics.”
EMD Millipore has also developed a cationic pDADMAC (poly diallyldimenthyl ammonium chloride) flocculation reagent targeted for biopharmaceutical applications which can be used as a pretreatment in combination with the Clarisolve® depth filters. pDADMAC treatment, in combination with Clarisolve® depth filters, provides an effective solution for harvesting high cell density cultures and can be easily incorporated into current clarification platforms.
Clarisolve® filters are available from lab, to pilot, to process scale in the industry leading disposable Pod format.
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Clarisolve® Depth Filters
MerckThe Clarisolve® depth filter is a novel clarification tool with a gradient density structure specifically designed to the particle size distributions of pretreated feed streams. Offering improved volumetric capacity and reduced turbidity over current available depth filters, the clarification step of pre-treated feeds can be processed in a significantly reduced footprint without the need for a secondary stage of clarification.The Clarisolve® depth filter is the first primary clarification offering with a gradient density structure specifically designed to the particle size distributions of pretreated feed streams. With improved volumetric capacity and reduced turbidity over currently available depth filters, the clarification step of pretreated feeds can be processed in a significantly reduced footprint without the need for a secondary stage of clarification.Available in Pod devices, the Clarisolve® depth filter provides the fastest and most efficient way to clarify high-density streams and easily transfer processes from upstream to downstream without the use of centrifugation.Clarisolve® Depth Filters Benefits: Reduced flushing volume (up to 93%). Provides fastest and most efficient way to clarify high-density pre-treated feed streams. Enables processing of pretreated feeds in a significantly reduced footprint with reduced flushing requirements. Eliminates the need for centrifugation and enables implementation of a fully single-use process train. Fully scalable from lab to pilot to process scale. Ability to go directly from primary clarification to downstream sterile filtration.