Simultaneous Determination of Prescription and Designer Benzodiazepines in Urine by SPE and LC-MS/MS
3 Jan 2017Benzodiazepines are prescribed for the treatment of anxiety, insomnia, muscle spasms, alcohol withdrawal and seizure prevention. They are also recurrently utilized as illegal recreational drugs and, similar to other commonly abused compounds, “ legal” alternatives have been developed in an attempt to bypass the controlled substances act. This application note describes a method for the simultaneous detection of prescription and synthetic Benzodiazepine in urine using UCT’s Clean Screen® XCEL I extraction columns in conjunction with the Selectra®DA HPLC column.
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SELECTRA® HPLC Columns
UCT, Inc.High purity, Type B, spherical silica support. 100A pore size. 1.8um, 3um, & 5um partical sizes. Variety of stationary phases.
Clean Screen® XCEL Solid Phase Extraction Columns
UCT, Inc.The Clean Screen® XCEL Solid Phase Extraction Columns are a line of sample prep phases designed to reduce the number of steps in the extraction, and therefore the amount of time and solvent necessary to complete the sample cleanup. Further advantages include reduced sample size and improved cleanliness and recovery. The Xcel I column will extract a wide array of basic drugs including benzodiazepines and opiates. The Xcel II column is designed solely for the extraction of the THC metabolite.