Application Note: Reconstruction of Human Epidermis Using BRANDplates® Insert System
8 January 2019

In the past decade new cell and tissue culture technologies have been generated to comply with the European legislation that restricts animal experiments to a minimum. Particularly, the improvement of culture conditions for reconstructed human full thickness skin and epidermis equivalents based on cell culture inserts, lead to a successful commercialization of these models. Today, with the help of artificial human tissues, pharmaceutical and cosmetic industry carry out tolerance, toxicology and irritation studies daily. In spite of every progress made in terms of media compositions and supplements, setup and handling of organotypic cultures still requires a lot of time and expertise.