Application Note: Intelligent Use of Retention Time during Multiple Reaction Monitoring for Faster and Extended Compound Screening with Higher Sensitivity and Better Reproducibility
21 August 2017

With the new Scheduled MRM™ Algorithm offered in the Analyst® software version 1.5, MRM transitions of the targeted analytes are monitored only around the expected retention time. Thus, automated MRM scheduling decreases the number of concurrent MRM transitions, allowing both the cycle time and the dwell time to be optimized for highest sensitivity, accuracy, and reproducibility. In addition Scheduled MRM™ allows the monitoring of many more MRM transitions in a single acquisition or to speed up the analysis by the use of UHPLC or to combine both concepts without compromising data quality.