Flow Chemistry Using Silica-Based Silia<i>MetS</i> Metal Scavengers, Silia<i>Bond</i> Functionalized Silica Gels and Silia<i>Cat</i> Heterogeneous Catalysts

SiliCycle is a pioneer in metal and organic scavenging solutions. We have nearly two decades of know-how in silica-grafting and scavenging technologies, and the broadest portfolio of scavengers.The removal of post-reaction residues has become a major issue in the pharmaceutical industry, among others. Purification of APIs by traditional methods (chromatography, activated carbon, distillation, etc.) often leads to problems such as high costs, time loss, low efficiency and reduced final yields. To overcome these drawbacks, SiliCycle has developed two families of scavengers that have significantly improved how chemists purify APIs: SiliaMetS Metal Scavengers and SiliaBond Organic Scavengers. The backbone of all those products is SiliCycle SiliaFlash® F60 (40-63 µm, 60 Å) which provides superior performance for all types of applications, due to its narrow particle size distribution and exceptional purity. What's more, we can provide different particle sizes or pore diameters on a custom basis.SiliCycle’s quality is famous and recognized, proven by countless applications and patents in literature. With our strong, extensive and confidential team of experts, your projects are in the best possible hands. SiliaMetS, your Metal Scavenging Final Solution Highly selective and cost-effective alternative for metal removal Expert team to help you consider every parameter: metal catalyst, solvent, residual reagent, by-products, structure of the API, temperature… Kits available for initial screenings. No leaching (no contamination). High selectivity (total recovery of the API). Wide range of metal species scavenged. Fast kinetics even at r.t. for maximal time-savings. Excellent stability (thermally and mechanically). New technologies compatibility (flow chemistry, microwave). Available both in Bulk or Fixed Bed (SPE or Flash cartridges) Mode. SiliaBond, your Best Bet for Removing Unwanted Organic Impurities and PGIs: Designed to react and bind a very large array of excess reagents and by-products High selectivity (total recovery of the API) Kits available for initial screenings Great for purification of potentially genotoxic impurities (PGI) Eliminates tedious post-reaction purifications Available both in Bulk for direct trapping or in SPE cartridges for the so-called “catch-and release” method Electrophile and Nucleophile Scavengers available Large team of experts always available to help you develop the best experimental conditions

Are you familiar with SiliCycle’s heterogeneous (silica-supported) catalysts? Gathered under the SiliaCat® brand, they are made using an innovative technology. The matrix consists of organically modified silica, described as a sol-gel hybrid organic-inorganic material. The SiliaCat family is an essential tool in the chemical manufacturing industry, as it opens the door for a “Green” and environmentally friendly synthetic route development. Recyclable and almost leach-proof, their use significantly reduces the amount of waste generated, eliminating costly downstream treatments.Because of the properties stated below, these heterogeneous catalysts are less hazardous to human health. And since they are supported, they significantly reduce the amount of handling and diminish the risks of accidents, associated with the use of their homogeneous analogs.Heterogeneous Catalysts - SiliaCat® Features & Benefits: High thermal and mechanical stability High reactivity and turnover numbers Excellent selectivity. Heterogeneous Catalysts - SiliaCat® Applications: Couplings - Suzuki - Stille - Heck - Sonogashira - Kumada Debenzylation Hydrogenation Hydrosylation Oxidation.