Analysis of Synthetic Cannabinoids from Urine for Forensic Toxicology Using Oasis HLB μElution Plates and CORTECS UPLC Columns

This application note details a strategy for the successful extraction and analysis of representatives of several different classes of synthetic cannabinoids from urine samples for forensic toxicology. Twenty-two synthetic cannabinoids and metabolites were extracted from urine using Waters Oasis HLB μElution plates. Analytical separation was achieved using Waters’ newly developed solid-core particle UPLC Column (CORTECS) with optimally packed 1.6 μm particles, resulting in excellent chromatographic performance and separation efficiency.