A Micropatterned Hepatocyte-Kupffer Cell Co-culture System to Study Inflammation in Drug Discovery

21 May 2014

This application note highlights the supplementation of the HepatoPac platform with primary Kupffer cells in order to mimic an inflammatory environment such as cytokine production and altered CYP450 activity.

Human HepatoPac™ Kits

Hepregen Corporation

Human HepatoPac™ kits are an ideal way to conduct all your DMPK, Predictive Toxicology & Mechanistic Toxicology applications. Begin dosing as early as 3 days after receiving the kit! Use our Human HepatoPac™ Triple Donor plates for the ultimate in convenience. HepatoPac™ co-cultures derived from 3 independent and highly characterized donors are provided on a single plate (8-wells from each donor).HepatoPac™ kits can be used for any assay that can be run using sandwich, monoculture plates or suspension cultures. Due to the extended in vitro functionality of HepatoPac™ co-cultures, Hepregen kits enable studies such as low turnover clearance or chronic toxicity studies that could not otherwise be performed.Human HepatoPac™ Kits Features: HT-ready format; 24- and 96-well plates Proprietary micropatterened co-culture Superior data for both slowly and rapidly metabolized drugs Culture longevity of up to 4 weeks Kits contain: Human HepatoPac™ Co-Cultures Maintenance Media Application-specific Media and additives Instructions for culture maintenance and application-specific protocols On-site customer training included

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A Micropatterned Hepatocyte-Kupffer Cell Co-culture System to Study Inflammation in Drug Discovery