Practical Solutions for Poorly Soluble Drugs
29 May 2014The therapeutic efficacy of a drug depends upon its bioavailability, which is directly correlated to its solubility. Many drugs, both in development and on the market, are poorly soluble in aqueous media, which can lead to poor bioavailability, and frequently results in variable dissolution rates. To achieve the desired drug concentration in systemic circulation to elicit a pharmacological response, solubility is paramount. Yet, less than 10% of new drug candidates demonstrate both high solubility and permeability, and 30–40% of the drugs that appear on the World Health Organisation (WHO) Essential Drug List were reported to be poorly water-soluble or lipophilic, based on the Biopharmaceutics Classification System (BCS). This whitepaper discusses laboratory scale formulation expertise and equipment in three distinct technologies.
Related Products
Request Quote for All Products
Aesica Formulation Development Service
AesicaFormulation Development SpecialistsWith a keen understanding of early stage development and clinical trial requirements, Aesica guides their customers through the processes of new medicine and material development for Phase 1 and Phase 2 clinical trials. They understand that their customers also need to maximise their budget effectiveness by minimising the amount of experimentation without sacrificing quality levels.Typical dosage forms we work with include tablets, capsules, liquids, suspensions, creams, ointments, inhaled and sterile pharmaceuticals. Aesica offer a suite of formulation development services… Pre-formulation Formulation and manufacturing Analysis and stability testing Manufacturing of clinical trial materials Regulatory support Technology transfer Aesica Formulation Development Service Benefits: Working with a fast-growing UK company with an expanding international presence Working with a flexible, dynamic, innovative organisation Working with full service development and manufacturing capability – from process development to commercial scale manufacture Working with a partner who can be trusted to deliver the highest standards in all areas: consultation, development, manufacture and delivery