Application Note: Faster Analysis of Radio Pharmaceuticals Using UPLC™ in Combination with Low Volume Radio Flow Cell
7 October 2016

Positron emission tomography (PET) has established itself as a dominant imaging modality in nuclear medicine and drug research. This application note details a study in which it was investigated if combination of an UPLC with a radioactivity detector would result in faster analyses of PET radiopharmaceuticals with a higher degree of sensitivity and efficiency. The study found that using Waters Acquity UPLC System with Berthold FlowStar LB513 radioactivity detector was a feasible for sensitive analysis of radiotracers. It was also found that this system could detect much lower radioactivity in comparison to Radio-HPLC systems.