Application Note: Fast Track Mass Spec Sample Prep
21 September 2018

Mass spectroscopy (MS) is a ubiquitous characterization tool that is vital to biologics development. Unfortunately many MS experiments require a compatible sample solution that differs from the supplied formulation to acquire high quality mass spectra. For example, electrospray ionization (ESI) experiments require a solution of water, organic solvent and organic acid as well as the removal of salts, detergents and buffering molecules. To remove these unwanted buffer components and to hit the right solution conditions, buffer exchange and/or dilution are commonly used.