Determination of Drug-to-Antibody Ratio for Antibody-Drug Conjugates Purified from Serum

26 Jan 2018

Antibody drug conjugates (ADCs) are used to create high local concentrations of cytotoxic drug at a specific target, with differing drug-to-antibody ratios (DARs). The DAR needs to be monitored closely, and this study demonstrates Agilent's complete ADC DAR determination solution.

Agilent 1290 Infinity II LC System

Agilent Technologies

The 1290 Infinity II LC System is an ultra-high performance LC that has market-leading sample capacity and is designed for the lowest dispersion for the most challenging ultra-HPLC experiments. The 1290 Infinity II LC system is designed to be both a HPLC and high-end UHPLC system in a single flow path, giving you robust and excellent performance no matter what application you are running while seamlessly integrating into your existing laboratory environment.

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Determination of Drug-to-Antibody Ratio for Antibody-Drug Conjugates Purified from Serum