Case Study: circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway
22 September 2023

This case study integrates whole transcriptome sequencing with technical assistance from Novogene. Leveraging the advancement of circRNA sequencing, small RNA sequencing, and mRNA sequencing, the authors not only reveal the oncogenic role of circPARD3 in laryngeal squamous cell carcinoma (LSCC) but also indicate that circPARD3 can serve as a new biomarker and target for autophagy detection and modulation, which might be used for controlling autophagy levels in different developmental stages of LSCC.