Application Note: A reliable and simple FIA-MS/MS method for the quantitation of amino acids and acylcarnitines in dried blood spots
10 November 2023

This application note from Thermo Fisher Scientific details a FIA-MS/MS method using the Thermo Scientific™ Vanquish™ MD HPLC and Thermo Scientific™ TSQ Quantis™ MD MS. The method, validated with ClinSpot™ LC-MS/MS Complete Kits, enables the detection of 12 amino acids and 13 acylcarnitines from dried blood spot samples. It fulfills the requirement for semi-quantitative determination of these compounds, crucial for newborn screening.