Tissue biodistribution of AAV-based gene therapy
18 Jan 2022AAV tissue biodistribution and cell tropism are essential pieces of information for every gene therapy development program. The RNAscope® ISH assay is a highly informative method for quantitative, cell-specific measurement of AAV vector and transgene expression. The RNAscope® assay can provide single-cell biodistribution data for every tissue type. In this application note, ACD demonstrates the use of the RNAscope® assay to determine therapeutic AAV vector cell tropism and transgene expression in non-human primate retina.
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RNAscope™ Chromogenic Assays
Advanced Cell DiagnosticsIndependent of your genes of interest, our easy RNA in situ hybridization assay uses common reagents and protocols; providing universal assay conditions. All RNA-ISH kits contain reagents in a convenient ready-to-use (RTU) format, and chromogenic dyes are available to interrogate a single or two genes simultaneously.