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Application Note: Novel interference removal opportunities with the NexION 5000 ICP-MS
17 March 2023

In this application note, PerkinElmer provides experimental data on novel interference removal opportunities using the NexION 5000® ICP-MS. Multi-quadrupole technology, in combination with controlled reactions in the Universal Cell (UCT) of the NexION 5000 ICP-MS, has opened new possibilities for spectral interference removal. As was described in the technical note “Interferences in ICP-MS: Do we still have to worry about them?”, the MS/MS and mass shift modes, in conjunction with three cell analytical modes (Std, KED and DRC), can solve many challenging problems, not previously possible using a single quadrupole system. This work is a continuation of a discussion on spectral interference removal and presents dynamic reactions with three gases (O2, NH3 and CH4) that, in tandem with multi-quadrupole technology, are a powerful tool in interference management on the NexION 5000 ICP-MS.