Application Note: Lyophilized beads: Efficient, scalable, production

29 September 2023

In this application note, BioDot addresses challenges in producing lyophilized beads at the microliter scale using conventional dispensing technologies. Conventional methods often result in inconsistent drop volumes, poor bead morphologies, and low throughput, leading to decreased yield and increased manufacturing costs. BioDot introduces a solution involving a horizontal droplet camera to measure drop volumes as an in-process quality control tool. Utilizing its patented Sphera^™ dispensing technology, BioDot achieved consistent lyophilized beads at different volumes, with yields of 96% or higher. The process, taking only one hour for dispensing and 75 hours for full lyophilization, significantly reduced defects and saved time and labor in lyobead production.

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