Application Note: Current and emerging immune checkpoint targets for immuno-oncology research
29 October 2020

Immune checkpoint molecules play a central role in regulating the activities of different immune cell types. These molecules have either stimulatory functions that promote immune cell activation to protect the host from invading pathogens and developing malignancies, or inhibitory functions that suppress immune cell activation to dampen inflammation, maintain immune homeostasis, and prevent tissue damage. Tumor cells frequently exploit immune checkpoint pathways by up-regulating the expression of ligands that activate inhibitory receptors on different immune cell types, allowing them to evade destruction by the host’s immune system. As a result, researchers have focused on targeting immune checkpoint molecules for cancer immunotherapy using either agonists of immune cell stimulatory receptors or antagonists of inhibitory receptors. This eBook details some of the current and emerging immune checkpoint molecules that are being investigated as potential targets for cancer immunotherapy and the products that we offer for studying these molecules.