SIRT1 is a member of the Sirtuin family of proteins related to the yeast Sir2 protein. Like Sir2 and other Sirtuins, SIRT1 is an NAD-dependent histone and protein deacetylase. SIRT1 catalyzes the removal of acetyl groups from a variety of protein substrates (NBS1, P53, Ku70, etc) as well as from lysine 16 of histone H4. SIRT1 is involved in the regulation of a number of cellular processes, including transcription, metabolism, DNA repair and aging.
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Clone: 2G1/F7
- Isotype: IgG1
- Quantity: 200 ug
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
- Immunofluorescence (IF)
- Immunoprecipitation (IP)
- Western Blotting (WB)
