RAT ANTI MOUSE CD86:RPE
Product Details
- Cat. No.
- MCA2463PE
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Rat
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Description
Rat anti mouse CD86 antibody, clone PO3 recognizes mouse CD86 (B7-2), a ~80 kDa cell surface glycoprotein, a member of the CD28/B7 family. In mouse CD86 is expressed at high levels on peripheral blood monocytes and dendritic cells, and at low levels on resting B and T-lymphocytes. Expression of CD86, on these cell populations, can be increased upon activation. CD86 has been identified, along with CD80 (B7-1), as a ligand for CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA4). CD28 and CTLA4 are two receptors that have opposing functions in T-cell stimulation. Interaction of CD86 with CD28 promotes a number of T-cell activities, whereas the binding of CD86 to CTLA4 inhibits T-cell responses. Rat anti mouse CD86 antibody, clone PO3 has been reported to block some co-stimulatory functions of CD86 (Nakajima et al. 1997).
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Mouse
- Isotype: IgG2b
Handling
- Quantity: 100 TESTS
- Storage: +4ºC DO NOT FREEZE
- Buffer: Phosphate buffered saline, 0.09% Sodium Azide, 1% BSA, 5% Sucrose
Applications
- Flow Cytometry (FC)