RABBIT ANTI NFkB p105
Product Details
- Cat. No.
- AHP2330
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
Western blot analysis of 3T3 cell lysate and Jurkat cell lysate
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Description
Rabbit anti NFkB p105 antibody recognizes Nuclear factor NF-kappa-B p105 subunit also known as DNA-binding factor KBF1 and Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. NF-kappa-B p105 is a large precursor protein that is cleaved at its C-terminus, containing a number of ankyrin repeats, by the ubiquitin/proteasome pathway into the NF-kappa-B p50 subunit. The p50 subunit is also known as NF-κB1 and interacts with members of the Rel protein family to form transcription factors. In the absence of stimulation an I-kappa-B inhibitory protein mediated sequestration mechanism ensures that the transcription factors remain in the cytoplasm. Upon stimulation, I-kappa-B proteins become phosphorylated, which results in their ubiquitylation and subsequent degradation by the 26S proteasome.The NF-kappa-B pathway plays a critical in mediating immune responses after infection and has been implicated in a variety of diseases ranging from autoimmune disorders to cancer.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Isotype: Polyclonal IgG
Handling
- Quantity: 50 µg
- Storage: -20ºC only
- Buffer: Phosphate buffered saline, 30% Glycerol, 0.5% BSA, 0.01% Thiomersal
Applications
- Western Blotting (WB)
