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CD82, also known as KAI1, C33 and TSPAN27 is a metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. It is believed that this protein plays a role in T-cell activation, and was later determined to act as a cancer metastasis suppressor gene. This protein is expressed at moderate to high levels in most tissues, but its expression is downregulated during tumor progression. The loss of KAI1 and p53 is associated with poor survival for prostate and other cancer patients. It associates with IGSF8, DARC, the ganglioside GM2, and the HTLV-1 Gag protein.