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Solute carrier family 15 member 2 (PEPT2) is a H+-coupled peptide transporter expressed in the kidney. The mammalian kidney is known to express a transport system specific for small peptides and pharmacologically active aminocephalosporins. This system is energized by a transmembrane electrochemical H+ gradient. PEPT2 contains twelve transmembrane domains and its structure is 50% identical and 70% similar to the human intestinal H+/peptide cotransporter.