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CA15-3 (MUC-1) is a type I transmembrane protein expressed in the apical membrane of highly polarized epithelial cells. CA15-3 is also overexpressed in epithelial tumors, such as breast or ovarian cancer. CA15-3 is composed of alpha and beta subunits. The alpha subunit has cell adhesive properties, whereas the beta subunit modulates signaling in the SRK, ERK, and NF-kappa B pathways. CA15-3 is used as a serological clinical marker of breast cancer to monitor response to breast cancer treatment and disease recurrence.