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Mouse MMR/CD206 Antibody

Bio-Techne
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Product Details

Cat. No.
AF2535
Type
Primary Antibody
Clonality
Polyclonal
Host
Goat
  • Detection of Mouse MMR/CD206 by Western Blot.

    Detection of Mouse MMR/CD206 by Western Blot.

  • Detection of Mouse MMR/CD206 by Western Blot.
Bio-Techne

The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our  Antibody Directory.

Product Overview

Detection of Mouse MMR/CD206 by Western Blot.

Mouse MMR/CD206 Antibody

Bio-Techne
0.0/5.0
|0 Reviews

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Bio-Techne

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  • Summary
  • Reviews

Description

The mouse Macrophage Mannose Receptor (MMR), also known as CD206 and MRC1 (mannose receptor C, type 1), is a 175 kDa scavenger receptor that is expressed on tissue macrophages, myeloid dendritic cells, and liver and lymphatic endothelial cells. It belongs to a family of receptors sharing similar protein structure that also includes DEC205, phospholipase A2 receptor, and Endo180. The mouse MMR protein is synthesized as a 1456 amino acid (aa) precursor that contains a 19 aa signal sequence, a 1369 aa extracellular region, a 21 aa transmembrane segment and a 47 aa cytoplasmic domain. Its extracellular region is composed of an N-terminal cysteine-rich domain, followed by a single fibronectin type II repeat, and eight C-type lectin carbohydrate recognition domains (CRD). Mouse to human, the extracellular region is 82% aa identical. The cysteine-rich domain mediates recognition of sulfated N-acetylgalactosamine, which occurs on some extracellular matrix proteins and is the terminal sugar of the unusual oligosaccharides present on pituitary hormones such as lutropin and thyrotropin. Several of the CRDs participate in the Ca2+-dependent recognition of carbohydrates showing a preference for branched sugars with terminal mannose, fucose or N‑acetylglucosamine. The cytoplasmic domain of MMR includes a tyrosine-based motif for internalization in clathrin-coated vesicles. Once internalized, ligands are released following acidification of phagosomes or endosomes, and the receptor recycles to the cell surface. MMR mediates phagocytosis upon binding to target structures that occur on a variety of pathogenic microorganisms including Gram-negative and Gram-positive bacteria, yeasts, parasites, and mycobacteria. MMR also functions to maintain homeostasis through the endocytosis of potentially harmful glycoproteins associated with inflammation.

Biological Information

  • Clonality: Polyclonal
  • Host: Goat
  • Reactivity: Mouse
  • Isotype: IgG

Handling

  • Quantity: 100 ug
  • Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
  • Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

Applications

  • Flow Cytometry (FC)
  • Immunohistochemistry (IHC)
  • Mass Cytometry (CyTOF)
  • Western Blotting (WB)
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