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GLP-1 stimulates glucose-dependent insulin release, therefore suppressing plasma glucagon levels, and stimulating glucose disposal in peripheral tissues. In addition, it plays an important role in gastric motility via growth-promoting activities on intestinal epithelium. In the pancreas, it regulates the hypothalamic pituitary axis through its affects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Finally it stimulates islet neogenesis and pancreatic beta cell proliferation while suppressing beta cell apoptosis.